HPR Series

The 1970s first documented retinoic acid's anti-aging efficacy, yet its high irritation restricted cosmetic use. By the 1990s, retinol became mainstream but showed significant instability—after 16 weeks, only 10% remains active—and caused frequent skin sensitivity. 

Hydroxypinacolone Retinoate (HPR) addresses these gaps as a direct-acting retinoid that binds RARs without conversion. Its stability is verified under accelerated conditions (50°C/light exposure), with no retinoic acid residue detected. Equivalent to 0.3% retinol at 0.04% concentration, HPR combines clinical efficacy with cosmetic safety, meeting modern formulation and consumer tolerance requirements.

This solvent-based liquid contains 10% HPR, using dimethyl isosorbide as a carrier to enhance stability. Accelerated testing (50°C/light exposure for 14 days) shows an HPR retention rate of 7.82%, superior to competitors (7.06%), with content remaining nearly unchanged after 16 weeks (retinol retention is only 10%). Compatible with pH 5.0–7.0 formulations, it ensures long-term anti-aging efficacy.

1.Barrier and Moisturizing Optimization
Clinical tests demonstrate 28-day use improves stratum corneum hydration by 18.7% and accelerates lipid homeostasis. This enhancement strengthens skin barrier function, reducing transepidermal water loss and increasing resistance to external irritants.

2.Anti-Aging Mechanism Enhancement
HPR upregulates type I/III collagen synthesis by 35% via TGF-β pathway activation while reinforcing basement membrane integrity. These biological actions directly correlate with measurable reductions in wrinkle depth and improved skin firmness in vivo.

3.Hypoallergenic and Anti-Irritant Properties
Patch testing (0.5% HPR solution) shows zero irritation reactions in 32 subjects, with signaling pathway modulation preventing inflammatory cytokine overexpression. This safety profile enables compatibility with sensitive skin formulations.

• Enhanced Stability: Accelerated testing (50°C/14 days) shows 7.82% HPR retention versus competitor's 7.06%. Six-month formulation studies detect zero retinoic acid in serums/creams, ensuring shelf-life stability.

• Solvent Optimization: 10% HPR concentration in dimethyl isosorbide enhances skin penetration. Sixteen-week stability shows near-constant content versus retinol's 10% retention, confirming delivery system efficacy.

• Broad Compatibility: Compatible with oil-in-water/anhydrous systems (pH 5.0-7.0). The solvent carrier prevents crystallization, maintaining homogeneity in final products.

Q1: How does HPR compare to other retinoids?  

A1: Compared to other forms of Vitamin A derivative, HPR delivers superior efficacy. Unlike retinyl esters that require multi-step conversion to become active, HPR is directly bioactive. While retinol oxidizes readily, HPR demonstrates enhanced stability. In contrast to tretinoin’s irritation potential, HPR’s esterified structure offers greater gentleness without photosensitivity, making it better suited for sensitive skin.

Q2: What are the applications and formulation suggestions for HPR?

A2:Recommended in night time and treatment applications 

Formulations containing additional active ingredients, photostabilizers, and even daily-use sunscreen demonstrate superior stability compared to single-component systems 

These conditions can help stabilize HPR: antioxidants, chelating agents, neutral pH, dark and air-tight containers 

The 1970s first documented retinoic acid's anti-aging efficacy, yet its high irritation restricted cosmetic use. By the 1990s, retinol became mainstream but showed significant instability—after 16 weeks, only 10% remains active—and caused frequent skin sensitivity. 

Hydroxypinacolone Retinoate (HPR) addresses these gaps as a direct-acting retinoid that binds RARs without conversion. Its stability is verified under accelerated conditions (50°C/light exposure), with no retinoic acid residue detected. Equivalent to 0.3% retinol at 0.04% concentration, HPR combines clinical efficacy with cosmetic safety, meeting modern formulation and consumer tolerance requirements.

Achieving water solubility via cosolvency technology, it has an HPR content of 2.0±0.2% and shows no precipitation after 21 days of room-temperature storage in 1%-10% aqueous solutions. Its heavy metal content (Pb≤10 mg/kg, As≤2 mg/kg) complies with international standards, resolving the application limitations of traditional vitamin A derivatives in aqueous systems.

1.Barrier and Moisturizing Optimization
Clinical tests demonstrate 28-day use improves stratum corneum hydration by 18.7% and accelerates lipid homeostasis. This enhancement strengthens skin barrier function, reducing transepidermal water loss and increasing resistance to external irritants.

2.Anti-Aging Mechanism Enhancement
HPR upregulates type I/III collagen synthesis by 35% via TGF-β pathway activation while reinforcing basement membrane integrity. These biological actions directly correlate with measurable reductions in wrinkle depth and improved skin firmness in vivo.

3.Hypoallergenic and Anti-Irritant Properties
Patch testing (0.5% HPR solution) shows zero irritation reactions in 32 subjects, with signaling pathway modulation preventing inflammatory cytokine overexpression. This safety profile enables compatibility with sensitive skin formulations.

• Water Solubility: Cosolvency technology enables immediate dissolution in aqueous systems. Solutions (1-10% concentration) maintain clarity and stability for 21 days at room temperature.

• Enhanced Bioavailability: The 2.0±0.2% active concentration demonstrates superior transdermal absorption. Heavy metal limits (Pb≤10mg/kg, As≤2mg/kg) meet ISO standards for global market compliance.

• Formulation Stability: Three-tier purity verification (HPLC, NMR, melting point) ensures batch consistency. This eliminates precipitation issues common with traditional vitamin A derivatives.

Q1: How does HPR compare to other retinoids?  

A1: Compared to other forms of Vitamin A derivative, HPR delivers superior efficacy. Unlike retinyl esters that require multi-step conversion to become active, HPR is directly bioactive. While retinol oxidizes readily, HPR demonstrates enhanced stability. In contrast to tretinoin’s irritation potential, HPR’s esterified structure offers greater gentleness without photosensitivity, making it better suited for sensitive skin.

Q2: What are the applications and formulation suggestions for HPR?

A2:Recommended in night time and treatment applications 

Formulations containing additional active ingredients, photostabilizers, and even daily-use sunscreen demonstrate superior stability compared to single-component systems 

These conditions can help stabilize HPR: antioxidants, chelating agents, neutral pH, dark and air-tight containers 

The 1970s first documented retinoic acid's anti-aging efficacy, yet its high irritation restricted cosmetic use. By the 1990s, retinol became mainstream but showed significant instability—after 16 weeks, only 10% remains active—and caused frequent skin sensitivity. 

Hydroxypinacolone Retinoate (HPR) addresses these gaps as a direct-acting retinoid that binds RARs without conversion. Its stability is verified under accelerated conditions (50°C/light exposure), with no retinoic acid residue detected. Equivalent to 0.3% retinol at 0.04% concentration, HPR combines clinical efficacy with cosmetic safety, meeting modern formulation and consumer tolerance requirements.

Adding 0.2% Glucosylrutin (GR) to W2 SACOS, it reduces HPR degradation rate by 3% in accelerated testing, achieving synergistic dual anti-aging via antioxidant-wrinkle reduction pathways. Certified by China IECIC (max 0.3% for leave-on products) and EU CosIng, it is suitable for daytime anti-photoaging applications.

1.Barrier and Moisturizing Optimization
Clinical tests demonstrate 28-day use improves stratum corneum hydration by 18.7% and accelerates lipid homeostasis. This enhancement strengthens skin barrier function, reducing transepidermal water loss and increasing resistance to external irritants.

2.Anti-Aging Mechanism Enhancement
HPR upregulates type I/III collagen synthesis by 35% via TGF-β pathway activation while reinforcing basement membrane integrity. These biological actions directly correlate with measurable reductions in wrinkle depth and improved skin firmness in vivo.

3.Hypoallergenic and Anti-Irritant Properties
Patch testing (0.5% HPR solution) shows zero irritation reactions in 32 subjects, with signaling pathway modulation preventing inflammatory cytokine overexpression. This safety profile enables compatibility with sensitive skin formulations.

• Dual-Action Synergy: Combining 0.2% glucosylrutin with HPR reduces degradation by 3% under accelerated conditions. This creates complementary antioxidant and collagen-boosting pathways.

• Advanced Delivery: Water-soluble technology enables seamless integration into daytime formulations. The combination meets EU cosmetic regulations while providing SPF-compatible anti-photoaging protection.

• Clinical Validation: Four-week studies show 80% participant agreement on elasticity improvement and spot reduction. 

Q1: How does HPR compare to other retinoids?  

A1: Compared to other forms of Vitamin A derivative, HPR delivers superior efficacy. Unlike retinyl esters that require multi-step conversion to become active, HPR is directly bioactive. While retinol oxidizes readily, HPR demonstrates enhanced stability. In contrast to tretinoin’s irritation potential, HPR’s esterified structure offers greater gentleness without photosensitivity, making it better suited for sensitive skin.

Q2: What are the applications and formulation suggestions for HPR?

A2:Recommended in night time and treatment applications 

Formulations containing additional active ingredients, photostabilizers, and even daily-use sunscreen demonstrate superior stability compared to single-component systems 

These conditions can help stabilize HPR: antioxidants, chelating agents, neutral pH, dark and air-tight containers